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OVERVIEW

5-MeO-DMT is a research chemical psychedelic of the tryptamine class, four to six times more powerful than its better-known cousin, DMT (N,N-dimethyltryptamine). It can be found in a wide variety of trees and shrubs, often alongside DMT and bufotenine (5-HO-DMT), as well as one species of toad. 5-MeO-DMT can also be synthetically produced.

In Central and South America, 5-MeO-DMT is most often sourced from Anadenanthera peregrina (yopo or cohoba) and Virola theiodora—both of which are traditionally harvested to make psychoactive snuff.

In keeping with its ceremonial use among indigenous Amazonians, 5-MeO-DMT shows great promise in the treatment of certain medical conditions. In fact, a single inhalation of the substance has been shown to greatly improve general well-being and mindfulness as well as reduce the symptoms of psychological disorders.

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While research into 5-MeO-DMT is limited, a few studies have supported the anecdotal evidence. In a recent preliminary study, 42 participants who took 5-MeO-DMT reported high levels of life satisfaction and mindfulness as well as lower levels of depression and anxiety. The effects persisted for four weeks, when a follow-up assessment was completed. These results support the findings of a survey of 362 people who had taken 5-MeO-DMT. After using the psychedelic, 80% of respondents reported improvements in anxiety and depression.

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5-MeO DMT cart, Vape Pen has seen a meteoric rise in popularity over the past few years as anecdotal reports of its potential as a healing agent have come to light. This has incentivized some bad practices among guides and other practitioners, including everything from overharvesting and the ecological strain on Sonoran Desert toad mentioned above, as well as sexual abuse and even unintended deaths in several documented cases.

EXPERIENCE

5-MeO-DMT is among the most powerful psychedelics one can get and can be powerful and intense in positive and negative ways. Although everyone will experience an experience that is unique to them however, there are some standard things to expect.

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Vaporizing or smoking 5-MeO-DMT powder is the most common route of administration. The effects are usually felt within the first 30 seconds after consumption, peaking from 1-15 minutes and lasting for up to half an hour. When taking synthetic 5-MeO-DMT, a threshold dose is around 1-2 mg, while a standard full dose is 8-12 mg. When naturally derived, the threshold dose is 5-10 mg and a standard full dose is 30-60 mg. One of the most popular aspects of the 5-MeO experience is the increase in the sense of touch, which may lead to sensory oversaturation. The body could also feel more weighted. The typical feeling of intense emotions is which range from intense fear to euphoria. In the initial phase of the event, excitement or anxiety are frequently experienced. Also, it is common to feel the overwhelming sensation of oneness in the world, an experience of being beyond time and space and simultaneously experiencing the fullness of both.

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5-MeO is utilized to heal in the hands of South American shamans for thousands of years, partly because of its capacity to induce mystical sensations. While research into the effects of the drug is restricted, recent research is affirming these claims.

In a study conducted among 362 adult adults, 80 percent of those who participated reported improvement in depression and anxiety following the use of 5-MeO-DMT. They also reported an improvement in wellbeing and satisfaction with life. More than that, these improvements were directly linked to spiritual experiences experienced in the course of an event. Respondents that experienced intense mystical experiences experienced higher levels of their personal meaning as well as spiritual meaning.

Dosing

5-MeO DMT doses are different depending on whether the substance is synthetic and naturally derived.

Synthetic

Small: 3-6 mg
Medium: 6-10 mg
Large: 11-15+ mg

Toad

Small: 10-20 mg
Medium: 20-40 mg
Large: 40-60+ mg

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